The discovery of penicillin was a significant ______(1) in the field of medicine. It not only revolutionized the treatment of infections but also ______(2) the way doctors approached disease management. Prior to this breakthrough, many infections were often ______(3). Today, however, antibiotics are a common ______(4) in healthcare. Nevertheless, overuse of these medications can lead to antibiotic ______(5), which poses a serious risk to public health.
Yukarıdaki paragrafta (4) numaralı boşluğa gelecek uygun ifade aşağıdakilerden hangisidir?